Pitt | Swanson Engineering
Iordanova, Bistra
Bioengineering Department
Iordanova, Bistra
Faculty
Research Assistant Professor
download vcard

Postdoctoral Training in Bioengineering and Radiology, University of Pittsburgh, 2016

PhD in Biophysics, Biological Sciences, Carnegie Mellon University, 2011

AS in Mathematics, Biology, City College of San Francisco, 2005

MA in Psychopathology, Sofia University, Bulgaria, 1998

Areas

Neurometabolic and neurovascular relationships in the brain

Oxygen metabolism and Neuroinflammation in Alzheimer's disease

Cerebral blood flow and metabolism after cardiac arrest

Therapies for improvement of impaired cerebral perfusion

 

Approaches

Two-photon imaging

Magnetic Resonance Imaging

Optical Intrinsic Signal

Electrophysiology

Optogenetics

Molecular and Cellular Engineering

 

Alzheimer's Association Research Grant, 2017-2019

Best Poster Award, Safar Symposium in Resuscitation Research, 2017

NINDS T32 Training Fellowship, Neurobiology of Neurological Disease, 2016-2017

Alzheimer's Imaging Consortium Fellowship, 2016

International Society for MRI in Medicine, Magna Cum Laude Award, 2014

International Society for MRI in Medicine, Summa Cum Laude Award, 2012

National Science Foundation Graduate Research Fellowship (NSF GRF), 2007-2010

Academic Excellence Award, Carnegie Mellon University, 2005

Biology Transfer Consortium Fellowship, UC Berkeley, Berkeley, CA, 2003

Science Mentor Award, City College of San Francisco, CA, 2002

Iordanova B, Li L, Clark RS, Manole MD. Alterations in Cerebral Blood Flow After Resuscitation from Cardiac Arrest. To appear in Frontiers in Pediatrics (2017).

Iordanova B, Murphy MC, Klunk WE and Vazquez AL. In vivo NADH fluorescence imaging of double transgenic Alzheimer's Disease mice reveals chronic tissue hypoxia. Alzheimer's & Dementia 12(7): P1047-P1048. (2016).

Iordanova B, Vazquez AL, Poplawsky A, Fukuda M, Kim SG. Neural and hemodynamic responses to optogenetic and sensory stimulation in the rat somatosensory cortex. J Cereb Blood Flow Metab. Jun;35(6):922-32. (2015).

Iordanova B, Hitchens TK, Robison C, Ahrens ET. Engineered mitochondrial ferritin as a magnetic resonance imaging reporter in mouse olfactory epithelium. PLoS One. Aug 30;8(8) (2013).

Iordanova B, Goins WF, Clawson DS, Hitchens TK, E.T. Ahrens ET.. Quantification of HSV1-mediated expression of the ferritin MRI reporter in the mouse brain. Gene Ther. Jun; 20(6):589-96. (2013).

Iordanova B, and Ahrens ET. In vivo magnetic resonance imaging of ferritin-based reporter visualizes native neuroblast migration. Neuroimage. Jan 16;59(2):1004-12 (2012).

Iordanova B, Robison CS, Goins WF, Ahrens ET. Single chain ferritin chimera as an improved MRI gene reporter. Prilozi. 31(2):151-5 (2010).

Iordanova B, Robison CS, Ahrens ET. Design and characterization of a chimeric ferritin with enhanced iron loading and transverse NMR relaxation rate. J Biol Inorg Chem. 15(6):957-65 (2010).

Iordanova B, Rosenbaum D, Norman D, Weiner M, Studholme C. MR imaging anatomy in neurodegeneration: a robust volumetric parcellation method of the frontal lobe gyri with quantitative validation in patients with dementia. Am J Neuroradiol. Sep;27(8):1747-54 (2006).

Rousseau F, Glenn OA, Iordanova B, Rodriguez-Carranza C, Vigneron DB, Barkovich JA, Studholme C. Registration-based approach for reconstruction of high-resolution in utero fetal MR brain images. Acad Radiol. Sep;13(9):1072-8 (2006).

Studholme C, Drapaca C,Iordanova B, Cardenas V. Deformation-based mapping of volume change from serial brain MRI in the presence of local tissue contrast change. IEEE Trans Med Imaging. May; 25:626-39 (2006).

Rodriguez-Carranza C, Rousseau F, Iordanova B, Glenn O., Vigneron D, Barkovich J, Studholme C. An ISO-surface folding analysis method applied to premature neonatal brain development Proc. SPIEMedical Imaging. Mar (2006).

Rousseau F, Glenn O, Iordanova B, Rodríguez-Carranza C, Vigneron D, Barkovich J, Studholme C. A novel approach to high resolution fetal brain MR imaging. Med Image Comput Comput Assist Interv. 548-555. (2005).

Iordanova B, "Alzheimer's Disease – Neuroimaging, Biomarkers and Beyond", Symposium on Aging and Alzheimer's Disease: Opportunities for Therapeutic Interventions hosted by Alzheimer's Association and University of Pittsburgh in Varna, Bulgaria (October 19-20, 2017)

Poplawsky AJ, Fukuda H, Iordanova B, Vazquez A, Kang BM, Kim J, Suh M, Kim SG. "What layer­specific fMRI responses in the rat olfactory bulb tell us about vascular regulation, hemodynamic spread, and the role of GABA cells in neurovascular coupling". 47th Society for Neuroscience Meeting in Washington, DC. (Nov 11-15, 2017)

Iordanova B, Kochanek PM, Alexander H, Fukuda M, Li L, Clark RSB, Manole MD , Vazquez AL. "In vivo Assessment of Cortical Neural and Metabolic Activity After Pediatric Cardiac Arrest", Brain 28th Symposium onCerebral Blood Flow, Metabolism and Function. Berlin, Germany. (April 1-4, 2017)

Iordanova B, Kochanek PM, Alexander H, Fukuda M, Li L, Clark RSB, Manole MD , Vazquez AL. "Cortical Neural and Metabolic Activity After Pediatric Cardiac Arrest", 15th Annual Safar Center Symposium in Pittsburgh, PA (May 22-23, 2017)

Iordanova B, Murphy MC, Klunk WE and Vazquez AL. "In vivo NADH fluorescence imaging of double transgenic Alzheimer’s Disease mice reveals chronic tissue hypoxia". Alzheimer’s Association International Conference 2016 in Toronto, Canada (Jul 24-28, 2016)

Jin T, Iordanova B, Wang P, and Kim SG. "Chemical Exchange-Sensitive Spin-Lock MRI of Glucose and Deoxyglucose in Brain Tumors". PENN-CEST Translational Imaging Symposium in Philadelphia, PA (Oct 25-28, 2015)

Iordanova B, Vazquez AL, Poplawsky AJ, Kozai TD, Fukuda M, Murphy M and Kim SG. "Optogenetic control of hemodynamic response in rat somatosensory cortex - fMRI and optical study" ISMRM 23rd Scientific Meeting in Milan, Italy. (May 10-16, 2014)

Iordanova B, Vazquez AL, Poplawsky AJ, Kozai TD, Fukuda M and Kim SG."Optogenetic control of neurovascular coupling along the transcallosal circuits in rat somatosensory cortex" SFN scientific meeting, San Diego, CA. (Nov 9-13, 2013)

Iordanova B, Hitchens TK, Robison C, Pusateri LK, Ahrens ET. "Mitochondrial ferritin with cytoplasmic localization as an MRI reporter in olfactory sensory neurons". ISMRM 20th Scientific Meeting in Melbourne, Australia (5-11 May, 2012)

Iordanova B and Ahrens ET. "In vivo magnetic resonance imaging of ferritin-based reporter visualizes native neuroblast migration." ISMRM 19th Scientific Meeting in Montréal, Québec, Canada. (7-13 May, 2011)

Iordanova B and Ahrens ET. "Chimeric ferritin as an MRI reporter gene in the mouse brain." Gordon research conference In Vivo Magnetic Resonance in Andover, NH. (25-30 July, 2010)

Iordanova B, Robison C and Ahrens ET. "Chimeric ferritin as a reporter for MRI" ISMRM 17th Scientific Meeting in Honolulu, Hawaii, HI. (18-24 April, 2009)

Iordanova B, Robison C, Goins WF and Ahrens ET. "MRI Transverse Relaxation Rate Correlates with Number of Viral Particles Expressing H-Ferritin in the CNS." ISMRM 16th Scientific Meeting in Toronto, Ontario, Canada. (3-9 May, 2008)

Iordanova B, Robison C, Goins WF and Ahrens ET. "HSV vector mediated expression of novel MRI reporters. 11th Annual Meeting of the American Society of Gene Therapy in Boston, MA. (May 28-June 1, 2008)

Studholme C, Rodriguez-Carranza C, Cardenas V, Iordanova B, Miller S, Mukherjee P, Glenn O, Vigneron D, Barkovich J, A Deformation Morphometry study of the Influences on the Pattern of Brain Tissue Development in Premature Neonates, Human Brain Mapping in Toronto, Ontario, Canada (April, 2005)