PITTSBURGH (January 11, 2018) … The covers of the Tissue Engineering, Part A and Advanced Healthcare Materials scientific journals in December highlighted two projects originating from the Swanson School of Engineering’s Little Lab, which focuses on developing
biomimetic therapies for human injury and disease.
“While it’s a coincidence that the two covers appeared in the same week, this achievement showcases the excellent work to change the paradigm of how we treat disease being done by all the team members of the Little Lab and its collaborators,” said
Steven R. Little, chair of the Department of Chemical and Petroleum Engineering and co-author of the two papers.
Both projects—one a research paper and the other a review—dealt with topics in “controlled delivery” and involved multi-disciplinary teams of researchers from the University of Pittsburgh departments of Chemical and Petroleum Engineering, Bioengineering,
Orthopaedic Surgery, and Ophthalmology.
“The research paper proposes a cell-free approach to bone engineering based on the directing the migration of the body own stem cells, while the review discusses innovative approaches to treat inflammatory eye diseases,” said
Riccardo Gottardi, research assistant professor in Pitt’s Department of Orthopaedic Surgery and a co-author of the two papers. Dr. Gottardi
has a second appointment in the Department of Chemical and Petroleum Engineering and helps Dr. Little run the Little Lab.
The cover of Tissue Engineering, Part A featured an image from the study “Programmed Platelet-Derived Growth Factor-BB and Bone Morphogenetic Protein-2 Delivery from a hybrid Calcium Phosphate/Alginate Scaffold” (DOI: 10.1089/ten.tea.2017.0027). The research paper described using a three-dimensional scaffold for releasing growth-stimulating proteins in a controlled manner to treat bone fractures that aren’t healing
The lead author of the paper was Emily Bayer, who recently graduated from her position as a trainee in the McGowan Institute for Regenerative Medicine Cellular Approaches to Tissue Engineering and Regeneration (CATER) Training Program. Bayer was a member of the Little Lab while working on the paper. The research team was joined by
Abhijit Roy, research assistant professor in the Department of Bioengineering, and Prashant N. Kumta, the Edward R. Weidlein Chair Professor with tenure at the Swanson School of Engineering and School of Dental Medicine.The cover of Advanced Healthcare Materials featured a graphic
for the study “Ocular Therapeutics: Modern Therapeutic Approaches for Noninfectious Ocular Diseases Involving Inflammation” (DOI: 10.1002/adhm.201700733).
The paper reviewed inflammatory eye disease treatments and was led by co-first authors Michelle L. Ratay and Elena Bellotti. Ratay, a graduate student researcher in the Department of Bioengineering, and Dr. Bellotti, a postdoctoral associate in the
Department of Chemical and Petroleum Engineering, are both members of the Little Lab.
Both projects examined topics in "controlled delivery" and involved multi-disciplinary teams of researchers from the Swanson School of Engineering.
Matt Cichowicz, Communications Writer, 1/11/2018
Contact: Paul Kovach