Dr. Lance Davidson is Professor in Bioengineering and a Wellington C. Carl
Faculty Fellow at the Swanson School of Engineering, with secondary
appointments in the Departments of Developmental Biology and Computational and
Systems Biology at the University of Pittsburgh and in the Biomedical
Engineering Department at Carnegie Mellon University. He is Director of the
Mechanics of Morphogenesis Laboratory. He is also is a Member of the Complex Biological Systems Group and a
Member of the Interdisciplinary Biomedical Graduate Program - Molecular
Genetics and Developmental Biology at the University of Pittsburgh School of
group works at the interface between engineering, physics, and biology. His lab
mechmorpho.org in the Biomedical Science Tower 3 (BST3)
has allowed him to work closely with engineers and biologists to integrate the
molecular genetic details of morphogenesis with cellular and tissue mechanics,
with the aim of helping design better artificial tissues and identifying the
mechanical sources of birth defects.
Dr. Davidson has
received funding from the National Institutes of Health, the National Science
Foundation, and the American Heart Association.
His research interests include:
Ph.D. in Biophysics, University of California at Berkeley, 1995
M.Sc. in Experimental Space Science, York University, 1986
B.S. in Physics, University of Illinois at Champaign-Urbana, 1984
(2017) Distinguished Lectureship. Richard Russell Memorial Lecture, University of Pittsburgh, Department of Biological Sciences..
(2013) Invited Panelist at the National Institutes of Health - 9th Structural Birth Defects Meeting.
(2013) University of Pittsburgh Provost's Innovation in Education Award.
(2012) Appointed Wellington C. Carl Faculty Fellow.
(2009) NSF Career Award.
(2008) American Heart Association Beginning Grant-in-Aid.
(1999) American Cancer Society Postdoctoral Fellowship.
(1999) Best Poster, Workshop on Advances in Cellular Imaging, W.M. Keck Center for Cellular Imaging, University of Virgina.
(1993) Fellowship to attend the Summer Course in Embryology at the Marine Biological Laboratory at Woods Hole, MA.
(1992) Fellowship to present a poster at the Gordon Conference on Theoretical Biology.
(1989) Systems in Integrative Biology - NIH National Research Service Award. U.C. Berkeley.
T. R. Jackson, H. Y. Kim, U. L. Balakrishnan, C. Stuckenholz, and L. A. Davidson (2017). Spatiotemporally
controlled mechanical cues drive progenitor mesenchymal-to-epithelial
transition enabling proper heart formation and function. Current Biology. 27:
1326–1335. PMID: 28434863 PMCID: PMC5497766
Chanet, S., Miller, C. J., Vaishnav, E. D., Ermentrout, B., Davidson, L. A., & Martin, A. C.
(2017). Actomyosin meshwork mechanosensing enables tissue shape to orient cell
force. Nature Communications, 8. PMID: 28504247, PMCID: PMC5440693,
L. A. Davidson (2017).
Mechanical design in embryos: mechanical signaling, robustness, and
developmental defects. Philosophical Transactions of the Royal Society, Part B.
Special Issue on Morphogenesis. PMID: 28348252 PMCID: PMC5379024
G. A. Stooke-Vaughan, L. A.
Davidson, and S. Woolner (2017). Xenopus as a model for studies in
mechanical stress and cell division. Genesis, The Journal of Genetics and
Development. PMID: 28095623 PMCID: PMC5276720
D. Vijayraghavan and L. A.
Davidson (2016). Mechanics of Neurulation: from classical to current
perspectives on the physical mechanics that shape, fold, and form the neural
tube. Birth Defects Research Part A: Clinical and Molecular Teratology. PMID:
J. J. Adibi, Y. Zhao, A. Cartus, P. Gupta, and L. A. Davidson (2016). Placental mechanics in the Zika-microcephaly
relationship. Cell Host & Microbe, 20(1), 9-11. Commentary on recent
studies. PMID: 27414496 DOI: 10.1016/j.chom.2016.06.013
H. Y. Kim*, T. R. Jackson*, and L.
A. Davidson (2016). On the role of mechanics in driving
mesenchymal-to-epithelial transitions. (* contributed equally) Seminars in Cell
and Developmental Biology. PMID: 27208723 PMCID: PMC5115991
B. Holt, J. H. Shawky, K. N. Dahl, L.
A. Davidson§, M. Islam§ (2016). Distribution of single-wall carbon
nanotubes in the Xenopus laevis embryo after microinjection. Applied
Toxicology. 36: 568-578. (§ contributed equally) PMID: 26510384.
B. Holt, J. H. Shawky, K. N. Dahl, L.
A. Davidson§, M. Islam§ (2016). Developing Xenopus embryos recover by
compacting and expelling single-wall carbon nanotubes. Journal of Applied
Toxicology. 36: 579-585. (§ contributed equally). PMID: 26153061
M. Hazar, Y. T. Kim, J. Song, P. R. LeDuc§, L. A Davidson§, W. C. Messner§ (2015). 3D bio-etching of a complex
composite-like embryonic tissue. Lab on a Chip, 15: 3293-9. (§ contributed
equally). PMID: 26138309. PMCID: 4519418
J. Song, J. H. Shawky, Y. T. Kim, M. Hazar, P. R. LeDuc§, M. Sitti§,
A. Davidson§ (2015). Controlled surface topography regulates collective 3D
migration by epithelial-mesenchymal composite embryonic tissues. Biomaterials,
58: 1-9. (§ contributed equally). PMID: 25933063. PMCID: 4437865
J. Zhou, S. Pal, S. Maiti, and L.
A. Davidson (2015). Force production
and mechanical accommodation during convergent extension. Development. 142,
692-701. PMID: 25670794. PMCID: 4402132
J. H. Shawky and L.A. Davidson (2015). Tissue mechanics and adhesion during embryo development. Developmental
Biology. 401: 152-164. (Special Issue on Adhesion). PMID: 25512299. PMCID:
E. M. McGreevy. D. Vijayraghavan, L.
A. Davidson and J. D. Hildebrand (2015). Shroom3 functions downstream of
planar cell polarity to regulate myosin II distribution and cellular
organization during neural tube closure. Biology Open. PMID: 25596276, PMCID:
R. Feroze*, J. H. Shawky*, M. von Dassow, and L. A. Davidson (2015). Mechanics of blastopore closure during
amphibian gastrulation. (* contributed equally) Developmental Biology.
398(1):57-67. PMID: 25448691, PMCID: 4317491
Y. T. Kim, M. Hazar, D. Vijayraghavan, J. Song, T. R. Jackson, S. D.
Joshi, L. A. Davidson§, W. C. Messner§, and P. R. LeDuc§. (2014)
Mechanochemical actuators of embryonic epithelial contractility. (§ contributed
equally) Proceedings of the National Academy of Sciences. 111, 14366-14371. PMID: 25246549, PMCID:
M. von Dassow, C. J. Miller, and L.
A. Davidson (2014). Biomechanics and the thermotolerance of development.
PLoS ONE. 9: e95670. PMID: 24776615, PMCID: 4002435
C. J. Miller and L. A. Davidson (2013).The interplay between cell signaling and mechanics in developmental
processes. Nature Reviews Genetics. 14: 733-744. PMID: 24045690. PMCID: 4056017
Kim, Y., Joshi, S.D., Davidson, L., Messner, W.C., and
LeDuc, P.R., "Mechanochemical actuators of embryonic epithelial
contractility," PNAS, Manuscript submitted for publication.
von Dassow, M., Miller, C.J., and Davidson, L.,
"Biomechanics and the thermotolerance of development," PLoS ONE,
Manuscript submitted for publication.
Edlund, A.F., Davidson, L., and Keller, R.E., 2013,
"Cell segregation, mixing, and tissue pattern in the spinal cord of the
Xenopus laevis neurula," Developmental Dynamics, vol.242, pp. 1134-1146.
Kim, H.Y., and Davidson, L., 2013, "Assembly of
chambers for stable long-term imaging of live Xenopus tissue," Cold Spring
Harbor Protocols, pdb. prot073882.
Kim, H.Y., and Davidson, L., 2013, "Investigating
morphogenesis in Xenopus embryos: Imaging strategies, processing, and
analysis," Cold Spring Harbor Protocols, pdb. top073890.
Kim, H.Y., and Davidson, L., 2013, "Microsurgical
approaches to isolate tissues from Xenopus embryos for imaging
morphogenesis," Cold Spring Harbor Protocols, pdb. prot073874.
Kim, H.Y., and Davidson, L., 2013, "Preparation and
use of reporter constructs for imaging morphogenesis in Xenopus embryos,"
Cold Spring Harbor Protocols, pdb. prot073866.
Miller, C.J., and Davidson, L., 2013, "The interplay
between cell signaling and mechanics in developmental processes," Nature
Reviews Genetics, vol.14, pp. 733-744.
Davidson, L., 2017 American Society for Cell Biology, Invited speaker in Cell Cycle
Subgroup session "Cell cycle regulation of morphogenetic behavior."
2017 ASCB Meeting.
Davidson, L., 2017 Richard Russell Memorial Lecture. University of Pittsburgh,
Department of Biological Sciences.
Davidson, L., 2017 Xenopus Resource Meeting, National Xenopus Resource, Marine
Biological Laboratory at Woods Hole, Invited Speaker
Davidson, L., 2017 NSF Cellular Biomanufacturing Workshop, George Mason University,
Davidson, L., 2017 King's College London, Department of Craniofacial Development and
Stem Cell Biology, Invited Seminar Speaker.
Davidson, L., 2017 Society for Developmental Biology, Organizing Committee for 76th
Annual Meeting in Minneapolis, MN.
Davidson, L., 2017 SB3C Summer Bioengineering Conference. Session co-organizer on
Mechanics of Development.
Davidson, L., 2017 University College London, MRC Laboratory for Molecular Cell Biology
and Institute for the Physics of Living Systems, Invited Seminar Speaker.
Davidson, L., 2017 University of California at Santa Barbara, Department of Mechanical
Engineering, Invited Seminar Speaker.
Davidson, L., 2017 Experimental Biology, FASEB, Chicago, IL. Invited Speaker, April
Davidson, L., 2017 Workshop on Morphogenesis: Celebration of D'Arcy Thompson, "On
Growth and Form" Centennial. Mathematical Biology Institute, Ohio State
University, Columbus, OH. Invited Speaker, Feb. 20-24. Participant, March 5-10.
Davidson, L., 2016 Biomedical Engineering Society Annual Meeting, Biomechanics Track
Davidson, L., 2016 Cornell University, Department of Biomedical Engineering, Invited
Davidson, L., 2016 Wayne State University, Department of Biology, Invited Seminar
Davidson, L., 2016 Society for Developmental Biology and International Society for
Developmental Biology, 75th Annual Meeting, Boston, MA. Invited Speaker, Aug.
Davidson, L., Charles, Illinois. Invited Speaker. Aug. 3-4.
Davidson, L., 2016 SB3C Summer Bioengineering Conference. Invited speaker in Special
Session "Non-Canonical Models for Mechanobiology — Insights from Plants
and Non-Mammalian Systems (Cell and Tissue).” June 30 - July 2. National City,
Davidson, L., 2016, 2017 Cold Spring Harbor Course on "Cell and Developmental
Biology of Xenopus". Instructor. April 9-12.
Davidson, L., 2016 Aspen Center for Physics Winter Conference "Physics of
Development and Disease," Invited Speaker. March 27-April 1.
Davidson, L., 2015 Stony Brook University, Department of Biochemistry, Invited Seminar
Davidson, L., 2015 GEM4 Summer School, Invited Lecturer, Carnegie Mellon University,
Davidson, L., 2015 Yale University, Department of Molecular and Cellular Biology,
Invited Seminar Speaker
Davidson, L., 2015 Workshop on Genetic and Generic Mechanisms of Development. Minnesota
Center for Philosophy of Science, University of Minnesota. April 23-26. One of
four invited Scientific Experts.
Davidson, L., 2015 Cold Spring Harbor Course on "Cell and Developmental Biology of
Xenopus". Instructor. April 17-20.
Davidson, L., 2015 Society for Developmental Biology Mid-Atlantic Region Meeting,
Princeton University, Invited Speaker in "Mechanisms of
Morphogenesis". March 27 - 28.
Davidson, L., 2015 West Virginia University. Department of Biological Sciences, Invited
Davidson, L., 2015 Cellular and Molecular Bioengineering Conference, St. Thomas, US
Virgin Islands. Jan. 6th-10th. "From Womb to Tomb: Mechanobiology of
Generation, Regeneration, and Degeneration." Invited Speaker.
Davidson, L., 2014 New York University. Department of Developmental Genetics, Symposium
on Morphogenesis. New York City, Dec. 6, Invited Speaker.
Davidson, L., 2014 The 62nd National Institute for Basic Biology Conference "Force
in Development", Okazaki Japan, Nov. 16-19, Co-Organizer
Davidson, L., Department of Molecular, Cellular, and Developmental Biology, Invited
Davidson, L., 2014 Workshop ‘Mechanobiology of Somitogenesis’, September 8th – 12th
2014, Leiden, The Netherlands, Invited Speaker
Davidson, L., 2014 16th International Xenopus Meeting, Pacific Grove California,
Davidson, L., 2014, "Emergent Behaviors of
Integrated Cellular Systems," World Conference on Biomechanics, Boston,
Davidson, L., 2014, "Mechanics of Tissue and
Organ Development," World Conference on Biomechanics, Boston,
Davidson, L., 2014, "Mechanobiology of
Somitogenesis'," Workshop, Leiden, The Netherlands.
Davidson, L., 2014, "Pattern Formation in
Cell Biology," Nonlinear Dynamics and Stochastic Methods: From
Neuroscience to Other Biological Applications, University of Pittsburgh, Pittsburgh,
Davidson, L., 2013, "Biomedical
Engineering," Departmental Seminar, Georgia Tech, Atlanta, Georgia.
Davidson, L., 2013, "Cellular Approaches to
Tissue Engineering and Regeneration (CATER)," University of Pittsburgh,
Davidson, L., 2013, "Computational and
Systems Biology," Departmental Seminar, University of Pittsburgh,
Davidson, L., 2013, "Morphogenesis in Living
Systems," Lecture, Paris, France.
Davidson, L., 2013, "Tissue Mechanobiology:
Tissue on the move," 15th International Conference on Biomedical
Engineering (ICMBE 2013), Singapore.