Pitt | Swanson Engineering
Weinbaum, Justin Sol
Bioengineering Department
Weinbaum, Justin Sol
Faculty
Research Assistant Professor
Office: Center for Bioengineering, Room 410
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Ph.D. in Molecular Cell Biology, Washington University in St. Louis, 2007

B.S. in Molecular Biophysics and Biochemistry, Yale University, 2000

Postdoctoral Training in Biomedical Engineering, University of Minnesota, 2007-2013

Cells, cultured

Collagen

Extracellular matrix

Extracellular matrix proteins

Muscle, smooth, vascular

Tissue engineering

Tissue scaffolds

Tropoelastin

Interdisciplinary tissue engineering research that exploits the cell-instructive properties of matricellular proteins. 

(2010) Midwest Affiliate Postdoctoral Fellowship, American Heart Association (declined).

(2010) Ruth L. Kirschstein National Research Service Award, NIH/NHLBI.

(2009) American Society for Cell Biology Postdoctoral Travel Award.

(2003) Graduate Research Fellowship, National Science Foundation.

(2003) Lucille P. Markey Fellowship in Human Pathobiology.

(1998) Chester Summer Scholar.

Blose, K.J., Pichamuthu, J.E., Weinbaum, J.S., and Vorp, D.A., 2014, "A Vacuum-Assisted Anchor for Manipulating Delicate Tissue," Manuscript submitted for publication.

Rao, J., Brown, B.N., Weinbaum, J.S., Ofstun, E., Makaroun, M.S., Humphrey, J.D., and Vorp, D.A., In press, "Distinct collagen organization and phenotypic profile of antigen presenting cells within the intraluminal thrombus of abdominal aortic aneurysm," Journal of Vascular Surgery.

Blose, K.J., Ennis, T.L., Arif, B., Weinbaum, J.S., Curci, J.A., and Vorp, D.A., 2014, "Periadventitial adipose-derived stem cell treatment halts elastase-induced abdominal aortic aneurysm progression.," Regenerative Medicine, vol.9, no.6, pp. 733-41.

Krawiec, J.T., Weinbaum, J.S., St Croix, C.M., Phillippi, J.A., Watkins, S.C., Rubin, J.P., and Vorp, D.A., 2014, "A Cautionary Tale for Autologous Vascular Tissue Engineering: Impact of Human Demographics on the Ability of Adipose-Derived Mesenchymal Stem Cells to Recruit and Differentiate into Smooth Muscle Cells.," Tissue Engineering. Part A.

Weinbaum, J.S., Schmidt, J.B., and Tranquillo, R.T., 2013, "Combating Adaptation to Cyclic Stretching By Prolonging Activation of Extracellular Signal-Regulated Kinase.," Cellular and Molecular Bioengineering, vol.6, no.3, pp. 279-286.

Blose, K.J., Krawiec, J.T., Weinbaum, J.S., and Vorp, D.A., 2013, "Bioreactors for Tissue Engineering Purposes; Chapter 15," in Regenerative Medicine Applications in Organ Transplantation, G. Orlando, ed., Academic Press, pp. 201-210.

Weinbaum, J.S., Qi, J., and Tranquillo, R.T., 2010, "Monitoring collagen transcription by vascular smooth muscle cells in fibrin-based tissue constructs.," Tissue Engineering. Part C, Methods, vol.16, no.3, pp. 459-67.

Weinbaum, J.S., Tranquillo, R.T., and Mecham, R.P., 2010, "The matrix-binding domain of microfibril-associated glycoprotein-1 targets active connective tissue growth factor to a fibroblast-produced extracellular matrix.," Macromolecular bioscience, vol.10, no.11, pp. 1338-44.

Ahmann, K.A., Weinbaum, J.S., Johnson, S.L., and Tranquillo, R.T., 2010, "Fibrin degradation enhances vascular smooth muscle cell proliferation and matrix deposition in fibrin-based tissue constructs fabricated in vitro.," Tissue Engineering. Part A, vol.16, no.10, pp. 3261-70.

Craft, C.S., Zou, W., Watkins, M., Grimston, S., Brodt, M.D., Broekelmann, T.J., Weinbaum, J.S., Teitelbaum, S.L., Pierce, R.A., Civitelli, R., Silva, M.J., and Mecham, R.P., 2010, "Microfibril-associated glycoprotein-1, an extracellular matrix regulator of bone remodeling.," The Journal of Biological Chemistry, vol.285, no.31, pp. 23858-67.

Black LD, 3.R.D., Meyers, J.D., Weinbaum, J.S., Shvelidze, Y.A., and Tranquillo, R.T., 2009, "Cell-induced alignment augments twitch force in fibrin gel-based engineered myocardium via gap junction modification.," Tissue Engineering. Part A, vol.15, no.10, pp. 3099-108.

Weinbaum, J.S., Broekelmann, T.J., Pierce, R.A., Werneck, C.C., Segade, F., Craft, C.S., Knutsen, R.H., and Mecham, R.P., 2008, "Deficiency in microfibril-associated glycoprotein-1 leads to complex phenotypes in multiple organ systems.," The Journal of Biological Chemistry, vol.283, no.37, pp. 25533-43.

Syedain, Z.H., Weinberg, J.S., and Tranquillo, R.T., 2008, "Cyclic distension of fibrin-based tissue constructs: evidence of adaptation during growth of engineered connective tissue.," Proceedings of The National Academy of Sciences of The United States of America, vol.105, no.18, pp. 6537-42.

Werneck, C.C., Vicente, C.P., Weinberg, J.S., Shifren, A., Pierce, R.A., Broekelmann, T.J., Tollefsen, D.M., and Mecham, R.P., 2008, "Mice lacking the extracellular matrix protein MAGP1 display delayed thrombotic occlusion following vessel injury.," Blood, vol.111, no.8, pp. 4137-44.

Estacion, M., Weinberg, J.S., Sinkins, W.G., and Schilling, W.P., 2003, "Blockade of maitotoxin-induced endothelial cell lysis by glycine and L-alanine.," American Journal of Physiology. Cell Physiology, vol.284, no.4, C1006-20.

Deverman, B.E., Cook, B.L., Manson, S.R., Niederhoff, R.A., Langer, E.M., Rosov√°, I., Kulans, L.A., Fu, X., Weinberg, J.S., Heinecke, J.W., Roth, K.A., and Weintraub, S.J., 2002, "Bcl-xL deamidation is a critical switch in the regulation of the response to DNA damage.," Cell, vol.111, no.1, pp. 51-62.

Wankhade, S., Yu, Y., Weinberg, J., Tainsky, M.A., and Kannan, P., 2000, "Characterization of the activation domains of AP-2 family transcription factors.," The Journal of biological chemistry, vol.275, no.38, pp. 29701-8.

Weinbaum, J.S., Krawiec, J.T., Pezzone, D.J., Rubin, J.P., and Vorp, D.A., 2014, "Defective Fibrinolytic Potential of Adipose-Derived Stem Cells from Diabetic Donors," American Society for Matrix Biology, Cleveland, OH.

Weinbaum, J.S., 2012, "Combating Adaptation to Stretch Conditioning Through Prolonged Activation of Extracellular Signal-Regulated Kinase," American Society for Matrix Biology, San Diego, CA.

Weinbaum, J.S., Syedain, Z.H., and Tranquillo, R.T., 2012, "Monitoring Collagen Expression in Mechanically Stimulated Bioartificial Arteries," Mathematical Biosciences Institute Workshop: Tissue Engineering and Regenerative Medicine, Columbus, OH.

Weinbaum, J.S., 2010, "The Matrix-Binding Domain Of Microfibril-Associated Glycoprotein-1 Targets Active Connective Tissue Growth Factor to a Fibroblast-Produced Extracellular Matrix," International Society for Applied Cardiovascular Biology, Cambridge, MA.